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Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids.

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第一作者： David F,Bodenstein

第一单位： Department of Pharmacology and Toxicology, University of Toronto, Medical Science Building, Room 4211, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

作者： David F,Bodenstein ^[1] ; Pavel,Powlowski ^[1] ; Kassandra A,Zachos ^[1] ; Dana,El Soufi El Sabbagh ^[1] ; Hyunjin,Jeong ^[1] ; Liliana,Attisano ^[2] ; Landon,Edgar ^[3] ; Douglas C,Wallace ^[4] ; Ana Cristina,Andreazza ^[5]

作者单位： Department of Pharmacology and Toxicology, University of Toronto, Medical Science Building, Room 4211, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. ^[1] Department of Biochemistry, University of Toronto, Toronto, ON, Canada.;Donnelly Centre, University of Toronto, Toronto, ON, Canada. ^[2] Department of Pharmacology and Toxicology, University of Toronto, Medical Science Building, Room 4211, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.;Department of Chemistry, University of Toronto, Toronto, ON, Canada. ^[3] Department of Biological Chemistry, Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA, USA.;Division of Human Genetics, Department of Pediatrics, Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, USA.;Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Department of Pharmacology and Toxicology, University of Toronto, Medical Science Building, Room 4211, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. ana.andreazza@utoronto.ca.;Department of Psychiatry, University of Toronto, Toronto, ON, Canada. ana.andreazza@utoronto.ca. ^[5]

关键词 Cerebral organoids Induced pluripotent stem cells Mitochondria Mitochondrial isolation Mitochondrial transplant

医学主题词人类(Humans);HEK293细胞(HEK293 Cells);线粒体(Mitochondria);诱导多能干细胞(Induced Pluripotent Stem Cells);类器官(Organoids)

DOI 10.1186/s13287-023-03436-y

PMID 37580812

发布时间 2023-11-22

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