Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis.

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作者： Min Seo,Kim ^[1] ; Minku,Song ^[1] ; Beomsu,Kim ^[1] ; Injeong,Shim ^[1] ; Dan Say,Kim ^[1] ; Pradeep,Natarajan ^[2] ; Ron,Do ^[3] ; Hong-Hee,Won ^[4]

作者单位： Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea. ^[1] Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[2] The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[3] Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea; Samsung Genome Institute, Samsung Medical Center, Seoul, Republic of Korea. Electronic address: wonhh@skku.edu. ^[4]

关键词 Mendelian randomization PRS PheWAS dyslipidemia eQTL multi-omics pQTL plasma lipids therapeutic targets

主题词人类(Humans);全基因组关联研究(Genome-Wide Association Study);多态性, 单核苷酸(Polymorphism, Single Nucleotide);血脂异常(Dyslipidemias);一元羧酸转运子(Monocarboxylic Acid Transporters)

DOI 10.1016/j.xcrm.2023.101112

PMID 37582372

发布时间 2024-02-07

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Cell reports. Medicine

2023年4卷9期

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Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis.

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Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis.

Cell reports. Medicine

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Cell reports. Medicine

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