首页> Journal of enzyme inhibition and medicinal chemistry> Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.

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第一作者： Samar,El-Kalyoubi

第一单位： Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.

作者： Samar,El-Kalyoubi ^[1] ; Mohamed M,Khalifa ^[2] ; Mahmoud T,Abo-Elfadl ^[3] ; Ahmed A,El-Sayed ^[4] ; Ahmed,Elkamhawy ^[5] ; Kyeong,Lee ^[6] ; Ahmed A,Al-Karmalawy ^[7]

作者单位： Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt. ^[1] Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt. ^[2] Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt.;Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, Egypt. ^[3] Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Giza, Egypt. ^[4] College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang, Republic of Korea.;Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. ^[5] College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang, Republic of Korea. ^[6] Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt. ^[7]

关键词 Molecular hybridisation apoptosis cytotoxicity dual Topo I/II inhibitors selenium nanoparticles

医学主题词硒(Selenium);嵌入剂(Intercalating Agents);细胞周期(Cell Cycle);DNA拓扑异构酶类, Ⅱ型(DNA Topoisomerases, Type II);纳米粒子(Nanoparticles);DNA(DNA)

DOI 10.1080/14756366.2023.2242714

PMID 37592917

发布时间 2023-08-24

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准确一般字义偏差语意偏离译文作用小提交