Functionally distinct regions of the locus <i>Leishmania major response 15</i> control IgE or IFNγ level in addition to skin lesions.

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作者： Imtissal,Krayem ^[1] ; Yahya,Sohrabi ^[1] ; Helena,Havelková ^[2] ; Elena S,Gusareva ^[3] ; Hynek,Strnad ^[1] ; Marie,Čepičková ^[1] ; Valeryia,Volkova ^[4] ; Iryna,Kurey ^[1] ; Jarmila,Vojtíšková ^[1] ; Milena,Svobodová ^[1] ; Peter,Demant ^[1] ; Marie,Lipoldová ^[5]

作者单位： Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czechia. ^[1] Department of Medical Genetics, Third Faculty of Medicine, Charles University, Prague, Czechia. ^[2] Department of Cardiology I-Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Westfälische Wilhelms-Universität, Münster, Germany. ^[3] Department of Genomics and Bioinformatics, Institute of Molecular Genetics of The Czech Academy of Sciences, Prague, Czechia. ^[4] Department of Parasitology, Faculty of Science, Charles University, Prague, Czechia. ^[5] Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States. ^[6]

关键词 Leishmania major advanced intercross line bioinformatics analysis fine mapping functional heterogeneity quantitative trait locus recombinant mapping susceptibility to infection

主题词动物(Animals);小鼠(Mice);硕大利什曼原虫(Leishmania major);皮肤疾病(Skin Diseases);干扰素γ(Interferon-gamma);细胞因子类(Cytokines);免疫球蛋白E(Immunoglobulin E)

DOI 10.3389/fimmu.2023.1145269

PMID 37600780

发布时间 2023-08-28

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准确一般字义偏差语意偏离译文作用小提交