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Combined inhibition of surface CD51 and γ-secretase-mediated CD51 cleavage improves therapeutic efficacy in experimental metastatic hepatocellular carcinoma.

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作者: Jianye,Cai [1] ; Jiancheng,Wang [2] ; Chenhao,Jiang [1] ; Linsen,Ye [3] ; Xinyi,He [4] ; Jianyang,Huang [4] ; Xiang,Sun [4] ; Zhijun,Ren [4] ; Xiaofan,Lai [5] ; Yuan,Qiu [4] ; Hongmiao,Wang [4] ; Guo,Lv [3] ; Jun,Zheng [3] ; Tongyu,Lu [3] ; Haitian,Chen [3] ; Yasong,Liu [3] ; Huaxin,Chen [6] ; Yuanjun,Guan [7] ; Yi,Wang [4] ; Tao,Wang [4] ; Jia,Yao [3] ; Xin,Sui [8] ; Yinqian,Kang [9] ; Yingcai,Zhang [3] ; Hua,Li [3] ; Jinkai,Wang [4] ; Weiqiang,Li [10] ; Guihua,Chen [3] ; Yang,Yang [11] ; Andy Peng,Xiang [12]
作者单位: Department of Hepatic Surgery and Liver Transplantation Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Key Laboratory of Liver Disease Research, Guangdong Engineering Laboratory for Transplantation, The Third Affiliated Hospital, Sun Yat-sen University, China; Centre for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China. [1] Scientific Research Centre, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China; Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China. [2] Department of Hepatic Surgery and Liver Transplantation Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Key Laboratory of Liver Disease Research, Guangdong Engineering Laboratory for Transplantation, The Third Affiliated Hospital, Sun Yat-sen University, China. [3] Centre for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China. [4] Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. [5] Biotherapy Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. [6] Core Facility Centre, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. [7] Surgical ICU, The Third Affiliated Hospital of Sun Yat-sen University, China. [8] Department of Anesthesiology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. [9] Centre for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China; Department of Histoembryology and Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China. [10] Department of Hepatic Surgery and Liver Transplantation Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Key Laboratory of Liver Disease Research, Guangdong Engineering Laboratory for Transplantation, The Third Affiliated Hospital, Sun Yat-sen University, China. Electronic address: yysysu@163.com. [11] Centre for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China; Department of Histoembryology and Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China. Electronic address: xiangp@mail.sysu.edu.cn. [12]
DOI 10.1016/j.jhep.2023.08.007
PMID 37604269
发布时间 2024-01-04
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