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首页> Cell death and differentiation> Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.

Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.

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第一作者： Huaizhen,Liang

第一单位： Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

作者： Huaizhen,Liang ^[1] ; Rongjin,Luo ^[1] ; Gaocai,Li ^[2] ; Weifeng,Zhang ^[1] ; Dingchao,Zhu ^[1] ; Di,Wu ^[1] ; Xingyu,Zhou ^[1] ; Bide,Tong ^[1] ; Bingjin,Wang ^[1] ; Xiaobo,Feng ^[1] ; Kun,Wang ^[1] ; Yu,Song ^[1] ; Cao,Yang ^[3]

作者单位： Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ^[1] Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China. ^[2] Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. 15927424693@163.com. ^[3] Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. caoyangunion@hust.edu.cn. ^[4]

主题词人类(Humans);甲基化(Methylation);赖氨酸(Lysine);蛋白质磷酸酶1(Protein Phosphatase 1);蛋白质组学(Proteomics);自噬(Autophagy);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);蛋白质加工, 转译后(Protein Processing, Post-Translational);碱性螺旋-环-螺旋亮氨酸拉链转录因子类(Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)

DOI 10.1038/s41418-023-01210-4

PMID 37605006

发布时间 2023-09-22

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Cell death and differentiation

Cell death and differentiation

2023年30卷9期

2135-2150页

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