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Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides.

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作者: Yue,Wang [1] ; Yanbo,Yu [1] ; Lixiang,Li [2] ; Mengqi,Zheng [3] ; Jiawei,Zhou [1] ; Haifan,Gong [2] ; Bingcheng,Feng [3] ; Xiao,Wang [1] ; Xuanlin,Meng [1] ; Yanyan,Cui [4] ; Yanan,Xia [1] ; Shuzheng,Chu [5] ; Lin,Lin [6] ; Huijun,Chang [7] ; Ruchen,Zhou [1] ; Mingjun,Ma [7] ; Zhen,Li [1] ; Rui,Ji [1] ; Ming,Lu [1] ; Xiaoyun,Yang [1] ; Xiuli,Zuo [1] ; Shiyang,Li [2] ; Yanqing,Li [3]
作者单位: Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China. [1] Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China. [2] Shandong Provincial Clinical Research Center for digestive disease, Jinan, China. [3] School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China. [4] Department of Pathology, Qilu Hospital of Shandong University, Jinan, China. [5] State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. [6] Advanced Medical Research Institute, Shandong University, Jinan, China. [7] Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China. [8] Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China. zuoxiuli@sdu.edu.cn. [9] Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China. zuoxiuli@sdu.edu.cn. [10] Shandong Provincial Clinical Research Center for digestive disease, Jinan, China. zuoxiuli@sdu.edu.cn. [11] Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China. lishiyang@sdu.edu.cn. [12] Advanced Medical Research Institute, Shandong University, Jinan, China. lishiyang@sdu.edu.cn. [13] Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, China. lishiyang@sdu.edu.cn. [14] Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China. liyanqing@sdu.edu.cn. [15] Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China. liyanqing@sdu.edu.cn. [16] Shandong Provincial Clinical Research Center for digestive disease, Jinan, China. liyanqing@sdu.edu.cn. [17]
DOI 10.1038/s41467-023-40565-7
PMID 37607912
发布时间 2023-11-19
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