Influence of CYP3A5 and ABCB1 polymorphisms on the pharmacokinetics of vincristine in adult patients receiving CHOP therapy.

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作者： Junichi,Nakagawa ^[1] ; Takenori,Takahata ^[2] ; Yu,Chen ^[3] ; Kensuke,Saito ^[3] ; Kosuke,Kamata ^[2] ; Takuto,Tachita ^[2] ; Satoru,Yamashita ^[2] ; Keigo,Saito ^[1] ; Kayo,Ueno ^[1] ; Atsushi,Sato ^[3] ; Hirotake,Sakuraba ^[2] ; Takenori,Niioka ^[4]

作者单位： Department of Pharmacy, Hirosaki University Hospital, 53 Hon-cho, Hirosaki, Aomori, 036-8563, Japan. ^[1] Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan. ^[2] Department of Medical Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan. ^[3] Department of Pharmacy, Hirosaki University Hospital, 53 Hon-cho, Hirosaki, Aomori, 036-8563, Japan. t-niioka@hirosaki-u.ac.jp. ^[4] Department of Pharmaceutical Science, Hirosaki University Graduate School of Medicine, 53 Hon-cho, Hirosaki, Aomori, Japan. t-niioka@hirosaki-u.ac.jp. ^[5]

关键词 Adult patients CHOP therapy CYP3A5 polymorphism Pharmacokinetics Vincristine (VCR)

主题词成年人(Adult);人类(Humans);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);基因型(Genotype);半衰期(Half-Life);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);长春新碱(Vincristine)

DOI 10.1007/s00280-023-04580-1

PMID 37610625

发布时间 2023-10-05

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