Effects of <i>CYP3A4</i> and <i>CYP2C9</i> genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226.

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第一作者： Delaney V,Rutherford

第一单位： Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

作者： Delaney V,Rutherford ^[1] ; Sarah,Medley ^[2] ; Nicholas C,Henderson ^[2] ; Christina L,Gersch ^[1] ; Ted A,Vandenberg ^[3] ; Kathy S,Albain ^[4] ; Shaker R,Dakhil ^[5] ; Nagendra R,Tirumali ^[6] ; Julie R,Gralow ^[7] ; Gabriel N,Hortobagyi ^[8] ; Lajos,Pusztai ^[9] ; Rita S,Mehta ^[10] ; Daniel F,Hayes ^[1] ; Kelley M,Kidwell ^[2] ; N Lynn,Henry ^[1] ; William E,Barlow ^[11] ; James M,Rae ^[1] ; Daniel L,Hertz ^[12]

作者单位： Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[1] Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. ^[2] Western University/Canadian Cancer Trials Group, London, ON, N5X 3K8, Canada. ^[3] Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA. ^[4] Cancer Center of Kansas, Wichita, KS 67214, USA. ^[5] Kaiser Permanente, Beaverton, OR 97005, USA. ^[6] American Society of Clinical Oncology, Alexandria, 22314, Virginia. ^[7] University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA. ^[8] Yale School of Medicine, New Haven, CT 06510, USA. ^[9] University of California Irvine Medical Center, Chao Family Comprehensive Cancer Center, Orange, CA 92868, USA. ^[10] SWOG Statistical Center, Seattle, WA 98109, USA. ^[11] Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI 48109, USA. ^[12]

关键词 anastrozole drug–drug interaction fulvestrant metabolism pharmacogenetics pharmacokinetics