Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.

导出 LinkOut

翻译打印收藏纠错

作者： Yuuki,Obata ^[1] ; Kazuo,Kurokawa ^[2] ; Takuro,Tojima ^[2] ; Miyuki,Natsume ^[3] ; Isamu,Shiina ^[4] ; Tsuyoshi,Takahashi ^[5] ; Ryo,Abe ^[6] ; Akihiko,Nakano ^[2] ; Toshirou,Nishida ^[7]

作者单位： Laboratory of Intracellular Traffic & Oncology, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address: yuobata@ncc.go.jp. ^[1] Live Cell Super-Resolution Imaging Research Team, RIKEN Center for Advanced Photonics, Wako, Saitama 351-0198, Japan. ^[2] Laboratory of Intracellular Traffic & Oncology, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Department of Applied Chemistry, Tokyo University of Science, Shinjuku-ku, Tokyo 162-8601, Japan. ^[3] Department of Applied Chemistry, Tokyo University of Science, Shinjuku-ku, Tokyo 162-8601, Japan. ^[4] Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan. ^[5] Tokyo University of Science, Noda, Chiba 278-8510, Japan. ^[6] National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan. ^[7]

关键词 AP1 CP: Cancer CP: Molecular biology GGA1 GIST Golgi/TGN KIT PI4KIIIβ PKD2 PLCγ2 mislocalization receptor tyrosine kinase

主题词人类(Humans);胃肠道间质肿瘤(Gastrointestinal Stromal Tumors);磷脂酶Cγ(Phospholipase C gamma);高尔基体(Golgi Apparatus);高尔基体外侧网络(trans-Golgi Network);原癌基因蛋白质类c-kit(Proto-Oncogene Proteins c-kit)

DOI 10.1016/j.celrep.2023.113035

PMID 37616163

发布时间 2023-10-14

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交