Comprehensive transcriptomics and metabolomics analyses reveal that hyperhomocysteinemia is a high risk factor for coronary artery disease in a chinese obese population aged 40-65: a prospective cross-sectional study.

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作者： Chong-Yu,Zhang ^[1] ; Ru-Qin,Xu ^[1] ; Xiao-Qiao,Wang ^[2] ; Lin-Feng,Sun ^[1] ; Pei,Mo ^[1] ; Ren-Jie,Cai ^[1] ; Xiao-Zhen,Lin ^[1] ; Cheng-Feng,Luo ^[1] ; Wen-Chao,Ou ^[1] ; Lie-Jing,Lu ^[3] ; Yun,Zhong ^[4] ; Jia-Yuan,Chen ^[5]

作者单位： Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guang Zhou, China. ^[1] Department of Anesthesiology, the Second Affiliated Hospital of Guangzhou Medical University, Guang Zhou, China. ^[2] Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guang Zhou, China. ^[3] Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guang Zhou, China. zhongyun@gzhmu.edu.cn. ^[4] , No.250 Changgang Road, Guangzhou, Haizhu district, China. zhongyun@gzhmu.edu.cn. ^[5] Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guang Zhou, China. JiayuanChen1987@gzhmu.edu.cn. ^[6] , No.250 Changgang Road, Guangzhou, Haizhu district, China. JiayuanChen1987@gzhmu.edu.cn. ^[7]

关键词 Cohort Coronary artery disease Hyperhomocysteinemia Metabolomics Obese ROC analysis S-adenosylhomocysteine