首页> Redox biology> Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

导出 LinkOut

翻译打印收藏纠错

第一作者： Lisa,Hong

第一单位： Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.

作者： Lisa,Hong ^[1] ; Dennis C,Braden ^[1] ; Yaoning,Zhao ^[2] ; John J,Skoko ^[1] ; Fei,Chang ^[3] ; Steven R,Woodcock ^[3] ; Crystall,Uvalle ^[3] ; Allison,Casey ^[1] ; Katherine,Wood ^[3] ; Sonia R,Salvatore ^[3] ; Alparslan,Asan ^[1] ; Trey,Harkness ^[1] ; Adeola,Fagunloye ^[1] ; Mortezaali,Razzaghi ^[4] ; Adam,Straub ^[3] ; Maria,Spies ^[4] ; Daniel D,Brown ^[5] ; Adrian V,Lee ^[5] ; Francisco,Schopfer ^[3] ; Bruce A,Freeman ^[3] ; Carola A,Neumann ^[6]

作者单位： Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA. ^[1] Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA; School of Medicine, Tsinghua University, Beijing, China. ^[2] Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. ^[3] Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA. ^[4] Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA. ^[5] Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA. Electronic address: neumannc@upmc.edu. ^[6]

关键词 Covalent inhibitor DNA repair Nitroalkenes RAD51 TNBC