When it is too much: Identifying butamben excess on the surface of pharmaceutical preformulation samples by Raman mapping.

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作者： Hery,Mitsutake ^[1] ; Gustavo H,Rodrigues da Silva ^[2] ; Eneida,de Paula ^[2] ; Márcia C,Breitkreitz ^[3]

作者单位： Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - Unicamp, Campinas 13083-862, SP, Brazil; Niels Bohr Institute, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark. Electronic address: hery.mitsutake@nbi.ku.dk. ^[1] Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - Unicamp, Campinas 13083-862, SP, Brazil. ^[2] Department of Analytical Chemistry, Institute of Chemistry, University of Campinas - Unicamp, Campinas 13084-970, SP, Brazil. ^[3]

关键词 API overload Distributional homogeneity index Homogeneity Local anesthetics NLC

主题词药用制剂(Pharmaceutical Preparations);辅药(Excipients);苯佐卡因(Benzocaine);脂类(Lipids)

DOI 10.1016/j.jpba.2023.115644

PMID 37633164

发布时间 2023-09-11

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