Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis.

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作者： Marta,Araújo ^[1] ; Diana,Moreira ^[2] ; Inês,Mesquita ^[1] ; Carolina,Ferreira ^[2] ; Ana,Mendes-Frias ^[3] ; Sónia,Barros-Carvalho ^[4] ; Ricardo Jorge,Dinis-Oliveira ^[5] ; Cláudio,Duarte-Oliveira ^[1] ; Cristina,Cunha ^[2] ; Agostinho,Carvalho ^[1] ; Bhaskar,Saha ^[2] ; Anabela,Cordeiro-da-Silva ^[1] ; Jérôme,Estaquier ^[2] ; Ricardo,Silvestre ^[1]

作者单位： Immunobiology of Inflammatory and Infectious Diseases (i3D), Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. ^[1] ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. ^[2] i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. ^[3] Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal. ^[4] Departamento de Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto (FFUP), Porto, Portugal. ^[5] TOXRUN - Toxicology Research Unit, University Institute of Health Sciences (IUCS), CESPU, CRL, Gandra, Portugal. ^[6] UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. ^[7] Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal. ^[8] MTG Research and Development Lab, Porto, Portugal. ^[9] National Centre for Cell Science, Pune, India. ^[10] INSERM U1124, Université Paris Cité, Paris, France. ^[11] Pathophysiology of Cell Death in Host-Pathogen Interactions, CHU de Québec - Université Laval Research Center, Québec City, Québec, Canada. ^[12]

关键词 T cell macrophage parasitic-protozoan