Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies.

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第一作者： Pouria,Salehi Nowbandegani

第一单位： Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. psalehin@broadinstitute.org.;Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. psalehin@broadinstitute.org.

作者： Pouria,Salehi Nowbandegani ^[1] ; Anthony Wilder,Wohns ^[2] ; Jenna L,Ballard ^[3] ; Eric S,Lander ^[4] ; Alex,Bloemendal ^[5] ; Benjamin M,Neale ^[6] ; Luke J,O'Connor ^[7]

作者单位： Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. psalehin@broadinstitute.org.;Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. psalehin@broadinstitute.org. ^[1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. awohns@broadinstitute.org.;Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. awohns@broadinstitute.org.;Stanford University School of Medicine, Stanford, CA, USA. awohns@broadinstitute.org. ^[2] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, USA. ^[3] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Biology, MIT, Cambridge, MA, USA.;Department of Systems Biology, Harvard Medical School, Boston, MA, USA. ^[4] Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[5] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[6] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. loconnor@broadinstitute.org.;Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. loconnor@broadinstitute.org. ^[7]

主题词人类(Humans);连锁不平衡(Linkage Disequilibrium);等位基因(Alleles);基因频率(Gene Frequency);遗传关联研究(Genetic Association Studies);单倍型(Haplotypes)

DOI 10.1038/s41588-023-01487-8

PMID 37640881

发布时间 2023-09-25

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