Carriers of rare damaging <i>CCR2</i> genetic variants are at lower risk of atherosclerotic disease.
作者:
Marios K,Georgakis [1]
;
Rainer,Malik [2]
;
Natalie R,Hasbani [3]
;
Gabrielle,Shakt [1]
;
Alanna C,Morrison [4]
;
Noah L,Tsao [5]
;
Renae,Judy [6]
;
Braxton D,Mitchell [4]
;
Huichun,Xu [5]
;
May E,Montasser [6]
;
Ron,Do [5]
;
Eimear E,Kenny [6]
;
Ruth J F,Loos [7]
;
James G,Terry [8]
;
John Jeffrey,Carr [7]
;
Joshua C,Bis [7]
;
Bruce M,Psaty [9]
;
W T,Longstreth [10]
;
Kendra A,Young [9]
;
Sharon M,Lutz [11]
;
Michael H,Cho [12]
;
Jai,Broome [13]
;
Alyna T,Khan [9]
;
Fei Fei,Wang [14]
;
Nancy,Heard-Costa [14]
;
Sudha,Seshadri [15]
;
Ramachandran S,Vasan [15]
;
Nicholette D,Palmer [16]
;
Barry I,Freedman [17]
;
Donald W,Bowden [17]
;
Lisa R,Yanek [18]
;
Brian G,Kral [19]
;
Lewis C,Becker [20]
;
Patricia A,Peyser [21]
;
Lawrence F,Bielak [22]
;
Farah,Ammous [23]
;
April P,Carson [23]
;
Michael E,Hall [23]
;
Laura M,Raffield [24]
;
Stephen S,Rich [25]
;
Wendy S,Post [26]
;
Russel P,Tracy [24]
;
Kent D,Taylor [25]
;
Xiuqing,Guo [27]
;
Michael C,Mahaney [28]
;
Joanne E,Curran [29]
;
John,Blangero [28]
;
Shoa L,Clarke [30]
;
Jeffrey W,Haessler [30]
;
Yao,Hu [30]
;
Themistocles L,Assimes [31]
;
Charles,Kooperberg [31]
;
Scott M,Damrauer [31]
;
Jerome I,Rotter [32]
;
Paul S,de Vries [32]
;
Martin,Dichgans [33]
作者单位:
Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
[1]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[2]
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
[3]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
[4]
Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
[5]
Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.
[6]
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
[7]
Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD.
[8]
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[9]
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[10]
The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[11]
Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[12]
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[13]
Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
[14]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[15]
Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.
[16]
Department of Epidemiology, University of Washington, Seattle, WA, USA.
[17]
Department of Neurology, University of Washington, Seattle, WA, USA.
[18]
Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora CO, USA.
[19]
Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Pilgrim Health Care and Harvard Medical School, Boston, MA, USA.
[20]
Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
[21]
Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[22]
Department of Biostatistics, University of Washington, Seattle, WA, USA.
[23]
Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
[24]
Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
[25]
Bigg's Institute for Alzheimer's Disease and neurodegenerative disorders, University of Texas Health Science Center, San Antonio, TX, USA.
[26]
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
[27]
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[28]
Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[29]
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[30]
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
[31]
Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
[32]
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
[33]
Center for Public Health Genomics, University of Virginia, Charlottesville, VA USA.
[34]
Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, MD USA.
[35]
Departments of Pathology & Laboratory Medicine, and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT USA.
[36]
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.
[37]
Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville TX USA.
[38]
Department of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA, USA.
[39]
Stanford Cardiovascular Institute, Stanford, CA, USA.
[40]
VA Palo Alto Health Care System, Palo Alto, CA, USA.
[41]
Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle WA 98109 USA.
[42]
Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
[43]
German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.
[44]
DOI
10.1101/2023.08.14.23294063
PMID
37645892
发布时间
2024-02-16
- 浏览0
medRxiv
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