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Carriers of rare damaging <i>CCR2</i> genetic variants are at lower risk of atherosclerotic disease.

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作者单位: Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany. [1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [2] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. [3] Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. [4] Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. [5] Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA. [6] Department of Medicine, University of Maryland School of Medicine, Baltimore, MD. [7] Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD. [8] The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [9] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [10] The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [11] Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [12] Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [13] Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA. [14] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. [15] Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA. [16] Department of Epidemiology, University of Washington, Seattle, WA, USA. [17] Department of Neurology, University of Washington, Seattle, WA, USA. [18] Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora CO, USA. [19] Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Pilgrim Health Care and Harvard Medical School, Boston, MA, USA. [20] Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. [21] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. [22] Department of Biostatistics, University of Washington, Seattle, WA, USA. [23] Department of Medicine, Boston University School of Medicine, Boston, MA, USA. [24] Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA. [25] Bigg's Institute for Alzheimer's Disease and neurodegenerative disorders, University of Texas Health Science Center, San Antonio, TX, USA. [26] Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. [27] Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. [28] Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. [29] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [30] Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. [31] Department of Medicine, University of Mississippi Medical Center, Jackson, MS. [32] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC. [33] Center for Public Health Genomics, University of Virginia, Charlottesville, VA USA. [34] Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, MD USA. [35] Departments of Pathology &amp; Laboratory Medicine, and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT USA. [36] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA. [37] Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville TX USA. [38] Department of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA, USA. [39] Stanford Cardiovascular Institute, Stanford, CA, USA. [40] VA Palo Alto Health Care System, Palo Alto, CA, USA. [41] Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle WA 98109 USA. [42] Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. [43] German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany. [44]
DOI 10.1101/2023.08.14.23294063
PMID 37645892
发布时间 2024-02-16
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