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Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists.

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第一作者： Assunta,Cirella

第一单位： Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain.

作者： Assunta,Cirella ^[1] ; Elixabet,Bolaños ^[1] ; Carlos,Luri-Rey ^[1] ; Claudia Augusta,Di Trani ^[1] ; Irene,Olivera ^[1] ; Gabriel,Gomis ^[2] ; Javier,Glez-Vaz ^[1] ; Beatrice,Pinci ^[2] ; Saray,Garasa ^[2] ; Sandra,Sánchez-Gregorio ^[1] ; Arantza,Azpilikueta ^[1] ; Iñaki,Eguren-Santamaria ^[1] ; Karmele,Valencia ^[3] ; Belén,Palencia ^[2] ; Maite,Alvarez ^[4] ; Maria C,Ochoa ^[4] ; Álvaro,Teijeira ^[4] ; Pedro,Berraondo ^[4] ; Ignacio,Melero ^[5]

作者单位： Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain. ^[1] Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain. ^[2] Program of Solid Tumors, Cima Universidad de Navarra, 31008 Pamplona, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain. ^[3] Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain. ^[4] Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain.;Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, 31008 Pamplona, Spain.;Department of Oncology, Clínica Universidad de Navarra, 28027 Madrid, Spain.;Centro Del Cancer de La Universidad de Navarra (CCUN), 31008 Pamplona, Spain.;Nuffield Department of Medicine (NDM), University of Oxford, Oxford OX3 7BN, UK. ^[5]

关键词 4-1BB CD137 IL-12 MT: Delivery Strategies TGF-β local immunotherapy mRNA

DOI 10.1016/j.omtn.2023.07.026

PMID 37650116

发布时间 2023-09-01

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