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Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus.

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第一作者： Roberta,Ragazzini

第一单位： Epithelial Stem Cell Biology & Regenerative Medicine Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Pears Building, Rosslyn Hill, London NW3 2PP, UK.

作者： Roberta,Ragazzini ^[1] ; Stefan,Boeing ^[2] ; Luca,Zanieri ^[1] ; Mary,Green ^[3] ; Giuseppe,D'Agostino ^[4] ; Kerol,Bartolovic ^[5] ; Ana,Agua-Doce ^[5] ; Maria,Greco ^[6] ; Sara A,Watson ^[7] ; Antoniana,Batsivari ^[8] ; Linda,Ariza-McNaughton ^[8] ; Asllan,Gjinovci ^[1] ; David,Scoville ^[9] ; Andy,Nam ^[9] ; Adrian C,Hayday ^[10] ; Dominique,Bonnet ^[8] ; Paola,Bonfanti ^[11]

作者单位： Epithelial Stem Cell Biology & Regenerative Medicine Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Pears Building, Rosslyn Hill, London NW3 2PP, UK. ^[1] Bioinformatics & Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. ^[2] Experimental Histopathology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. ^[3] Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Plasticell Limited, Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage SG1 2FX, UK. ^[4] Flow Cytometry Core, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. ^[5] Single Cell Facility, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK. ^[6] Epithelial Stem Cell Biology & Regenerative Medicine Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. ^[7] Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. ^[8] NanoString Technologies Inc., Seattle, WA, USA. ^[9] Immunosurveillance Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK. ^[10] Epithelial Stem Cell Biology & Regenerative Medicine Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Pears Building, Rosslyn Hill, London NW3 2PP, UK. Electronic address: p.bonfanti@ucl.ac.uk. ^[11]

关键词 3D imaging BCAM epithelial stem cells human thymus in?vitro self-renewal multipotency single-cell clonal assay spatial phenotyping spatial transcriptomics stem cell niche

医学主题词人类(Humans);细胞分化(Cell Differentiation);干细胞(Stem Cells);胸腺(Thymus Gland);细胞, 培养的(Cells, Cultured);上皮细胞(Epithelial Cells);萎缩(Atrophy)

DOI 10.1016/j.devcel.2023.08.017

PMID 37652013

发布时间 2026-02-15

基金项目

ERC_/European Research Council/International 639429/ERC_/European Research Council/International FC001045/CRUK_/Cancer Research UK/United Kingdom

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