Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML.

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作者： Yongping,Zhang ^[1] ; Shuting,Jiang ^[2] ; Fuhong,He ^[3] ; Yuanyuan,Tian ^[2] ; Haiyang,Hu ^[3] ; Li,Gao ^[1] ; Lin,Zhang ^[2] ; Aili,Chen ^[3] ; Yixin,Hu ^[1] ; Liyan,Fan ^[2] ; Chun,Yang ^[3] ; Bi,Zhou ^[2] ; Dan,Liu ^[3] ; Zihan,Zhou ^[1] ; Yanxun,Su ^[1] ; Lei,Qin ^[4] ; Yi,Wang ^[5] ; Hailong,He ^[2] ; Jun,Lu ^[2] ; Peifang,Xiao ^[3] ; Shaoyan,Hu ^[2] ; Qian-Fei,Wang ^[3]

作者单位： Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, 215025, China. ^[1] CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. ^[2] University of Chinese Academy of Sciences, Beijing, 100049, China. ^[3] Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, 215025, China. ^[4] SuZhou Hospital of Anhui Medical University, Suzhou, China. ^[5] Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, 215025, China. hsy139@126.com. ^[6] CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. wangqf@big.ac.cn. ^[7] University of Chinese Academy of Sciences, Beijing, 100049, China. wangqf@big.ac.cn. ^[8]

关键词 AML CD69 Chemotherapy resistance HSC-like Leukemia stem cell Oxidative phosphorylation Residual tumor cell Single-cell RNA sequencing

主题词成年人(Adult);人类(Humans);儿童(Child);白血病, 髓样(Leukemia, Myeloid);造血干细胞(Hematopoietic Stem Cells);基因表达谱(Gene Expression Profiling);信号传导(Signal Transduction)

DOI 10.1186/s13059-023-03031-7

PMID 37653425

发布时间 2023-11-21

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