首页> European journal of medicinal chemistry> Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy.

Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy.

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第一作者： Zhijie,Wang

第一单位： ShenZhen Hospital, Southern Medical University, Shenzhen, 518000, PR China; School of Science, China Pharmaceutical University, Nanjing, 211198, PR China.

作者： Zhijie,Wang ^[1] ; Donglin,Wu ^[2] ; Xiaofei,Zhao ^[2] ; Canlin,Liu ^[2] ; Siming,Jia ^[2] ; Qindi,He ^[2] ; Fei,Huang ^[2] ; Zitian,Cheng ^[2] ; Tao,Lu ^[3] ; Yadong,Chen ^[4] ; Yun,Chen ^[5] ; Pei,Yang ^[6] ; Shuai,Lu ^[7]

作者单位： ShenZhen Hospital, Southern Medical University, Shenzhen, 518000, PR China; School of Science, China Pharmaceutical University, Nanjing, 211198, PR China. ^[1] School of Science, China Pharmaceutical University, Nanjing, 211198, PR China. ^[2] State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: lutao@cpu.edu.cn. ^[3] Laboratory of Molecular Design and Drug Discovery, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: chenyadong@gmail.com. ^[4] Edmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, PR China. Electronic address: cheny653@mail.sysu.edu.cn. ^[5] Experimental Teaching Demonstration Center of Pharmaceutical Chemistry, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: pharmyp@163.com. ^[6] School of Science, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address: lu_shuai@cpu.edu.cn. ^[7]

关键词 AML Dual inhibitor FLT3 HDAC

医学主题词人类(Humans);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);fms样酪氨酸激酶3(fms-Like Tyrosine Kinase 3);细胞凋亡(Apoptosis);白血病, 髓样, 急性(Leukemia, Myeloid, Acute)

DOI 10.1016/j.ejmech.2023.115759

PMID 37659198

发布时间 2023-09-18

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