The role of vaccination route with an adenovirus-vectored vaccine in protection, viral control, and transmission in the SARS-CoV-2/K18-hACE2 mouse infection model.

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第一作者： Alexandria,Dickson

第一单位： Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO, United States.

作者： Alexandria,Dickson ^[1] ; Elizabeth,Geerling ^[1] ; E Taylor,Stone ^[1] ; Mariah,Hassert ^[1] ; Tara L,Steffen ^[1] ; Taneesh,Makkena ^[1] ; Madeleine,Smither ^[1] ; Katherine E,Schwetye ^[2] ; Jianfeng,Zhang ^[3] ; Bertrand,Georges ^[3] ; M Scot,Roberts ^[3] ; John J,Suschak ^[3] ; Amelia K,Pinto ^[1] ; James D,Brien ^[1]

作者单位： Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO, United States. ^[1] Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States. ^[2] Altimmune Inc., Gaithersburg, MD, United States. ^[3]

关键词 SARS-CoV-2 intramuscular vaccination intranasal vaccination vaccine efficacy vaccine immunogenicity virus transmission

主题词动物(Animals);小鼠(Mice);腺病毒科(Adenoviridae);疫苗(Vaccines);接种(Vaccination);腺病毒科感染(Adenoviridae Infections);动物, 基因修饰(Animals, Genetically Modified)

DOI 10.3389/fimmu.2023.1188392

PMID 37662899

发布时间 2023-09-13

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