PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer.

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第一作者： Kento,Kawasaki

第一单位： Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

作者： Kento,Kawasaki ^[1] ; Kazuhiro,Noma ^[2] ; Takuya,Kato ^[1] ; Toshiaki,Ohara ^[3] ; Shunsuke,Tanabe ^[1] ; Yasushige,Takeda ^[1] ; Hijiri,Matsumoto ^[1] ; Seitaro,Nishimura ^[1] ; Tomoyoshi,Kunitomo ^[1] ; Masaaki,Akai ^[1] ; Teruki,Kobayashi ^[1] ; Noriyuki,Nishiwaki ^[1] ; Hajime,Kashima ^[1] ; Naoaki,Maeda ^[1] ; Satoru,Kikuchi ^[1] ; Hiroshi,Tazawa ^[4] ; Yasuhiro,Shirakawa ^[5] ; Toshiyoshi,Fujiwara ^[1]

作者单位： Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. ^[1] Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. knoma@md.okayama-u.ac.jp. ^[2] Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.;Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. ^[3] Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.;Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan. ^[4] Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.;Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan. ^[5]

关键词 Cancer-associated fibroblasts Esophageal cancer Immune checkpoint inhibitors Program cell death ligand 1 Programmed cell death 1

主题词动物(Animals);小鼠(Mice);人类(Humans);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);食管肿瘤(Esophageal Neoplasms);叉头转录因子类(Forkhead Transcription Factors);肿瘤微环境(Tumor Microenvironment)

DOI 10.1007/s00262-023-03531-2

PMID 37668710

发布时间 2023-11-18

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