4-Oxo-β-Lactams as Novel Inhibitors for Rhomboid Proteases.

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第一作者： Jian,Yang

第一单位： Laboratory of, Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Herestraat 49, box 901b, 3000, Leuven, Belgium.

作者： Jian,Yang ^[1] ; Luís A R,Carvalho ^[2] ; Shanping,Ji ^[1] ; Suyuan,Chen ^[3] ; Rui,Moreira ^[2] ; Steven H L,Verhelst ^[1]

作者单位： Laboratory of, Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Herestraat 49, box 901b, 3000, Leuven, Belgium. ^[1] Department of Pharmaceutical Sciences and Medicines, Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal. ^[2] Leibniz Institut für Analytische Wissenschaften - ISAS - e.V, Otto-Hahn Strasse 6b, 44227, Dortmund, Germany. ^[3]

关键词 activity-based protein profiling beta-lactams covalent inhibitors intramembrane proteases protease inhibitors

主题词 β内酰胺类(beta-Lactams);内肽酶类(Endopeptidases);丝氨酸蛋白酶类(Serine Proteases)

DOI 10.1002/cbic.202300418

PMID 37671979

发布时间 2023-11-07

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