Understanding and Tackling Immune Responses to Adeno-Associated Viral Vectors.

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作者： Helena,Costa-Verdera ^[1] ; Carmen,Unzu ^[2] ; Erika,Valeri ^[1] ; Sahil,Adriouch ^[3] ; Gloria,González Aseguinolaza ^[2] ; Federico,Mingozzi ^[4] ; Anna,Kajaste-Rudnitski ^[5]

作者单位： San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCSS Ospedale San Raffaele, Milan, Italy. ^[1] DNA and RNA Medicine Division, CIMA, Universidad de Navarra, IdisNA, Pamplona, Spain. ^[2] University of Rouen, INSERM, U1234, Pathophysiology Autoimmunity and Immunotherapy (PANTHER), Normandie University, Rouen, France. ^[3] Vivet Therapeutics S.L., Pamplona, Spain; and. ^[4] Spark Therapeutics, Inc., Philadelphia, Pennsylvania, USA. ^[5]

关键词 AAV adaptive immunity gene therapy immune responses innate immunity viral restriction

主题词动物(Animals);人类(Humans);补体激活(Complement Activation);免疫, 先天(Immunity, Innate);炎症(Inflammation);模型, 动物(Models, Animal)

DOI 10.1089/hum.2023.119

PMID 37672519

发布时间 2023-09-21

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