A Study in Scaffold Hopping: Discovery and Optimization of Thiazolopyridines as Potent Herbicides That Inhibit Acyl-ACP Thioesterase.

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第一作者： Steven A G,Abel

第一单位： Research and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, 65926, Frankfurt am Main, Germany.

作者： Steven A G,Abel ^[1] ; Neanne,Alnafta ^[1] ; Elisabeth,Asmus ^[1] ; Birgit,Bollenbach-Wahl ^[1] ; Ralf,Braun ^[1] ; Jan,Dittgen ^[1] ; Anne,Endler ^[2] ; Jens,Frackenpohl ^[1] ; Jörg,Freigang ^[3] ; Elmar,Gatzweiler ^[1] ; Ines,Heinemann ^[1] ; Hendrik,Helmke ^[1] ; Bernd,Laber ^[1] ; Gudrun,Lange ^[1] ; Anu,Machettira ^[1] ; Gillian,McArthur ^[1] ; Thomas,Müller ^[1] ; Magdalena,Odaybat ^[1] ; Anna M,Reingruber ^[1] ; Sina,Roth ^[1] ; Christopher H,Rosinger ^[1] ; Dirk,Schmutzler ^[1] ; Wolfgang,Schulte ^[1] ; Rhea,Stoppel ^[1] ; Jörg,Tiebes ^[1] ; Giulio,Volpin ^[4] ; David M,Barber ^[1]

作者单位： Research and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, 65926, Frankfurt am Main, Germany. ^[1] Targenomix GmbH, Am Mühlenberg 11, 14476, Potsdam, Germany. ^[2] Research and Development, Hit Discovery, Bayer AG, Crop Science Division, Alfred-Nobel-Straße 50, 40789, Monheim am Rhein, Germany. ^[3] Research and Development, Small Molecules Technologies, Bayer AG, Crop Science Division, Industriepark Höchst, 65926, Frankfurt am Main, Germany. ^[4]

关键词 acyl-ACP thioesterase crop protection herbicides scaffold hopping thiazolopyridines

主题词除莠剂(Herbicides);杂草(Plant Weeds);硫酯水解酶类(Thiolester Hydrolases);农作物(Crops, Agricultural);除草(Weed Control)

DOI 10.1021/acs.jafc.3c02490

PMID 37677080

发布时间 2023-12-17

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