首页> Stem cell research & therapy> Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome.

Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome.

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第一作者： Dongsheng,Cai

第一单位： Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchun East Road, Hangzhou, 310016, China.

作者： Dongsheng,Cai ^[1] ; Xiaochen,Wang ^[2] ; Yaxun,Sun ^[1] ; Hangping,Fan ^[2] ; Jingjun,Zhou ^[2] ; Zongkuai,Yang ^[2] ; Hangyuan,Qiu ^[1] ; Jue,Wang ^[2] ; Jun,Su ^[2] ; Tingyu,Gong ^[2] ; Chenyang,Jiang ^[3] ; Ping,Liang ^[4]

作者单位： Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchun East Road, Hangzhou, 310016, China. ^[1] Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.;Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China. ^[2] Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchun East Road, Hangzhou, 310016, China. cyjiang@zju.edu.cn. ^[3] Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China. pingliang@zju.edu.cn.;Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China. pingliang@zju.edu.cn. ^[4]

关键词 Brugada syndrome Nav1.5 SCN5A Wnt/β-catenin signaling iPSC-CMs

医学主题词人类(Humans);Brugada综合征(Brugada Syndrome);肌细胞, 心脏(Myocytes, Cardiac);诱导多能干细胞(Induced Pluripotent Stem Cells);β连环素(beta Catenin)

DOI 10.1186/s13287-023-03477-3

PMID 37679791

发布时间 2023-11-22

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