Cryoelectron tomography reveals the multiplex anatomy of condensed native chromatin and its unfolding by histone citrullination.

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作者： Nathan,Jentink ^[1] ; Carson,Purnell ^[1] ; Brianna,Kable ^[1] ; Matthew T,Swulius ^[2] ; Sergei A,Grigoryev ^[3]

作者单位： Penn State University College of Medicine, Department of Biochemistry & Molecular Biology, H171, Milton S. Hershey Medical Center, P.O. Box 850, 500 University Drive, Hershey, PA 17033, USA. ^[1] Penn State University College of Medicine, Department of Biochemistry & Molecular Biology, H171, Milton S. Hershey Medical Center, P.O. Box 850, 500 University Drive, Hershey, PA 17033, USA. Electronic address: mts286@psu.edu. ^[2] Penn State University College of Medicine, Department of Biochemistry & Molecular Biology, H171, Milton S. Hershey Medical Center, P.O. Box 850, 500 University Drive, Hershey, PA 17033, USA. Electronic address: sag17@psu.edu. ^[3]

关键词 3D modeling chromatin higher-order structure cryoelectron microscopy epigenetic gene regulation histone histone citrullination linker DNA nucleosome nucleosome array folding tomography

主题词人类(Humans);核小体(Nucleosomes);组蛋白类(Histones);异染色质(Heterochromatin);染色质(Chromatin)

DOI 10.1016/j.molcel.2023.08.017

PMID 37683647

发布时间 2024-09-22

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