Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells.

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作者： Yuta,Mitobe ^[1] ; Shuhei,Suzuki ^[2] ; Yurika,Nakagawa-Saito ^[1] ; Keita,Togashi ^[3] ; Asuka,Sugai ^[1] ; Yukihiko,Sonoda ^[1] ; Chifumi,Kitanaka ^[4] ; Masashi,Okada ^[1]

作者单位： Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. ^[1] Department of Neurosurgery, School of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. ^[2] Department of Clinical Oncology, School of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. ^[3] Department of Ophthalmology and Visual Sciences, School of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. ^[4] Research Institute for Promotion of Medical Sciences, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. ^[5]

关键词 HDM4 HDMX MDM2 antagonist MDMX combination therapy drug repositioning drug repurposing feedback mechanism glioma meningioma

DOI 10.3390/cancers15174326

PMID 37686602

发布时间 2023-09-11

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准确一般字义偏差语意偏离译文作用小提交