Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism.

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第一作者： Daniel,Zaienne

第一单位： Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany.

作者： Daniel,Zaienne ^[1] ; Laura,Isigkeit ^[1] ; Julian A,Marschner ^[2] ; Silke,Duensing-Kropp ^[2] ; Georg,Höfner ^[2] ; Daniel,Merk ^[2]

作者单位： Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany. ^[1] Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany. ^[2]

关键词 cancer natural product synthesis neurodegeneration retinoid X receptor transcription factor

主题词倍半萜类(Sesquiterpenes);茚类(Indenes);维甲类X受体(Retinoid X Receptors);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear)

DOI 10.1002/cmdc.202300404

PMID 37697963

发布时间 2024-03-26

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准确一般字义偏差语意偏离译文作用小提交