Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin.

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作者： Solène,Denolly ^[1] ; Hongbo,Guo ^[1] ; Miriam,Martens ^[1] ; Anna,Płaszczyca ^[1] ; Pietro,Scaturro ^[2] ; Vibhu,Prasad ^[3] ; Kessiri,Kongmanas ^[1] ; Nuntaya,Punyadee ^[4] ; Adisak,Songjaeng ^[5] ; Dumrong,Mairiang ^[4] ; Andreas,Pichlmair ^[5] ; Panisadee,Avirutnan ^[4] ; Ralf,Bartenschlager ^[5]

作者单位： Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg University, Medical Faculty Heidelberg , Heidelberg, Germany. ^[1] Technical University of Munich, School of Medicine, Institute of Virology , Munich, Germany. ^[2] Leibniz Institute of Virology , Hamburg, Germany. ^[3] Division of Dengue Hemorrhagic Fever Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand. ^[4] Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand. ^[5] Molecular Biology of Dengue and Flaviviruses Research Team, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency , Pathumthani, Thailand. ^[6] Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand. ^[7]

关键词 flavivirus glycoproteins host targeting therapy nonstructural protein nuclear transport protein secretion