首页> Science translational medicine> SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8<sup>+</sup> T cells.

SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8<sup>+</sup> T cells.

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第一作者： Sherly I,Celada

第一单位： Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA.

作者： Sherly I,Celada ^[1] ; Clarice X,Lim ^[2] ; Alexandre F,Carisey ^[3] ; Scott A,Ochsner ^[4] ; Carlos F,Arce Deza ^[5] ; Praveen,Rexie ^[2] ; Fernando,Poli De Frias ^[6] ; Rafael,Cardenas-Castillo ^[5] ; Francesca,Polverino ^[5] ; Markus,Hengstschläger ^[2] ; Konstantin,Tsoyi ^[5] ; Neil J,McKenna ^[4] ; Farrah,Kheradmand ^[7] ; Thomas,Weichhart ^[2] ; Ivan O,Rosas ^[5] ; Luc,Van Kaer ^[8] ; Lindsay J,Celada ^[9]

作者单位： Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA. ^[1] Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna 1090, Austria. ^[2] William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX 77030, USA.;Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.;Department of Cell and Molecular Biology, St. Jude Children's Hospital, Memphis, TN 38105, USA. ^[3] Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. ^[4] Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA. ^[5] Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.;Mount Sinai Medical Center, Miami Beach, FL 33140, USA. ^[6] Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.;Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. ^[7] Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. ^[8] Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.;Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. ^[9]