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Cross-talk between B cells, microglia and macrophages, and implications to central nervous system compartmentalized inflammation and progressive multiple sclerosis.

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第一作者： Hanane,Touil

第一单位： Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

作者： Hanane,Touil ^[1] ; Rui,Li ^[1] ; Leah,Zuroff ^[1] ; Craig S,Moore ^[2] ; Luke,Healy ^[3] ; Francesca,Cignarella ^[4] ; Laura,Piccio ^[5] ; Samuel,Ludwin ^[6] ; Alexandre,Prat ^[7] ; Jennifer,Gommerman ^[8] ; Frederick C,Bennett ^[9] ; Dina,Jacobs ^[1] ; Joyce A,Benjamins ^[10] ; Robert P,Lisak ^[10] ; Jack P,Antel ^[3] ; Amit,Bar-Or ^[11]

作者单位： Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada. ^[2] Neuroimmunology Unit, Montréal Neurological Institute, McGill University, Canada. ^[3] Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, USA. ^[4] Charles Perkins Centre and School of Medical Sciences, The University of Sydney, Camperdown, NSW, Australia. ^[5] Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada. ^[6] Université de Montréal Centre de Recherche du CHUM (CRCHUM) and Department of Neuroscience, Université de Montréal, 900 Saint Denis Street, Montréal, QC, H2X 0A9, Canada. ^[7] Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada. ^[8] Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[9] Departments of Neurology and Biochemistry, Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA. ^[10] Department of Neurology and Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: amitbar@pennmedicine.upenn.edu. ^[11]

关键词 CNS-compartmentalized inflammation Human B cells Human macrophage Human microglia Multiple sclerosis