A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1<sup>G93A</sup> model of ALS.

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作者： Daniela,Gerovska ^[1] ; Julie B,Noer ^[2] ; Yating,Qin ^[2] ; Quratul,Ain ^[3] ; Donjetë,Januzi ^[4] ; Matthias,Schwab ^[3] ; Otto W,Witte ^[3] ; Marcos J,Araúzo-Bravo ^[3] ; Alexandra,Kretz ^[5]

作者单位： Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, 20014, San Sebastian, Spain. ^[1] Department of Biology, Section for Ecology and Evolution, University of Copenhagen, 2100, Copenhagen, Denmark. ^[2] Department of Neurology, Jena University Hospital, 07747, Jena, Thuringia, Germany. ^[3] Department of Internal Medicine IV, Hepatology, Jena University Hospital, 07747, Jena, Thuringia, Germany. ^[4] Jena Center for Healthy Ageing, Jena University Hospital, Jena, Thuringia, Germany. ^[5] Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, 20014, San Sebastian, Spain. mararabra@yahoo.co.uk. ^[6] Basque Foundation for Science, IKERBASQUE, 48013, Bilbao, Spain. mararabra@yahoo.co.uk. ^[7] Max Planck Institute for Molecular Biomedicine, Computational Biology and Bioinformatics Group, 48149, Münster, North Rhine-Westphalia, Germany. mararabra@yahoo.co.uk. ^[8] Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), 48940, Leioa, Spain. mararabra@yahoo.co.uk. ^[9] Department of Neurology, Jena University Hospital, 07747, Jena, Thuringia, Germany. alexandra.kretz@med.uni-jena.de. ^[10] Jena Center for Healthy Ageing, Jena University Hospital, Jena, Thuringia, Germany. alexandra.kretz@med.uni-jena.de. ^[11]

关键词 ALS circulome ALS proteome Amyotrophic lateral sclerosis (ALS)Circular DNA DNA damage and repair Differential analysis Extrachromosomal circular DNA Genetic heterogeneity Neurodegeneration eccDNA

DOI 10.1186/s13578-023-01116-1

PMID 37705092

发布时间 2023-11-21

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