Refining chimeric antigen receptors via barcoded protein domain combination pooled screening.

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作者： Xavier,Rios ^[1] ; Osmay,Pardias ^[2] ; Marc A,Morales ^[2] ; Pradyot,Bhattacharya ^[2] ; Yibin,Chen ^[2] ; Linjie,Guo ^[2] ; Chunchao,Zhang ^[2] ; Erica J,Di Pierro ^[2] ; Gengwen,Tian ^[1] ; Gabriel A,Barragan ^[1] ; Pavel,Sumazin ^[3] ; Leonid S,Metelitsa ^[4]

作者单位： Center for Advanced Innate Cell Therapy, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. ^[1] Center for Advanced Innate Cell Therapy, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. ^[2] Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. ^[3] Center for Advanced Innate Cell Therapy, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. Electronic address: lsmeteli@texaschildrens.org. ^[4]

关键词 cancer immunotherapy cell therapy chimeric antigen receptors protein engineering

主题词人类(Humans);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);T淋巴细胞(T-Lymphocytes);肿瘤(Neoplasms);免疫球蛋白G(Immunoglobulin G);免疫疗法, 过继(Immunotherapy, Adoptive);抗原, CD19(Antigens, CD19)

DOI 10.1016/j.ymthe.2023.09.008

PMID 37705245

发布时间 2024-11-02

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