Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers.

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作者： Arunpandian,Balaji ^[1] ; Craig A,Bell ^[2] ; Zachary H,Houston ^[1] ; Kim R,Bridle ^[3] ; Berit,Genz ^[4] ; Nicholas L,Fletcher ^[2] ; Grant A,Ramm ^[5] ; Kristofer J,Thurecht ^[6]

作者单位： Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, Australia. ^[1] Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, Australia; Australian Research Council Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Queensland 4072, Australia. ^[2] Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia; Gallipoli Medical Research Institute, Greenslopes Private Hospital, Brisbane, Queensland 4120, Australia. ^[3] Mater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland 4102, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. ^[4] Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. ^[5] Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, Australia; Australian Research Council Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: k.thurecht@uq.edu.au. ^[6]

关键词 Biodegradable polymers Hepatic fibrosis Hepatic stellate cells Ligand density RAFT ROP pH-sensitive micelles

主题词小鼠(Mice);动物(Animals);配体(Ligands);肝硬化(Liver Cirrhosis);肝(Liver);纳米粒子(Nanoparticles)

DOI 10.1016/j.biomaterials.2023.122318

PMID 37708659

发布时间 2023-11-06

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