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Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants.

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第一作者： Sounak,Sahu

第一单位： Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.

作者： Sounak,Sahu ^[1] ; Teresa L,Sullivan ^[1] ; Alexander Y,Mitrophanov ^[2] ; Mélissa,Galloux ^[3] ; Darryl,Nousome ^[4] ; Eileen,Southon ^[1] ; Dylan,Caylor ^[1] ; Arun Prakash,Mishra ^[1] ; Christine N,Evans ^[5] ; Michelle E,Clapp ^[5] ; Sandra,Burkett ^[1] ; Tyler,Malys ^[2] ; Raj,Chari ^[5] ; Kajal,Biswas ^[1] ; Shyam K,Sharan ^[1]

作者单位： Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America. ^[1] Statistical Consulting and Scientific Programming, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland, United States of America. ^[2] Independent bioinformatician, Marseille, France. ^[3] CCR Bioinformatics Resource, Leidos Biomedical Sciences, Inc. Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. ^[4] Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. ^[5]