首页> Computational biology and chemistry> New thiazolidine-2,4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity studies.

New thiazolidine-2,4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity studies.

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第一作者： Hazem,Elkady

第一单位： Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Hazemelkady@azhar.edu.eg.

作者： Hazem,Elkady ^[1] ; Abdelrahman A,Abuelkhir ^[2] ; Mahmoud,Rashed ^[3] ; Mohammed S,Taghour ^[3] ; Mohammed A,Dahab ^[3] ; Hazem A,Mahdy ^[3] ; Alaa,Elwan ^[3] ; Hanan A,Al-Ghulikah ^[4] ; Eslam B,Elkaeed ^[5] ; Ibrahim M,Ibrahim ^[6] ; Dalal Z,Husein ^[7] ; Ahmed,Metwaly ^[8] ; Ibrahim H,Eissa ^[9]

作者单位： Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Hazemelkady@azhar.edu.eg. ^[1] Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo 11884, Egypt. ^[2] Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. ^[3] Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia. ^[4] Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia. ^[5] Biophysics Department, Faculty of Science, Cairo University, Giza 12613, Egypt. ^[6] Chemistry Department, Faculty of Science, New Valley University, El-Kharja 72511, Egypt. ^[7] Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt. ^[8] Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg. ^[9]

关键词 Anti-proliferative DFT Docking MD simulations Thiazolidine-2,4-dione VEGFR-2