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Chronic cadmium exposure triggered ferroptosis by perturbing the STEAP3-mediated glutathione redox balance linked to altered metabolomic signatures in humans.

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第一作者： Ping,Deng

第一单位： Department of Occupational Health (Key Laboratory of Electromagnetic Radiation Protection, Ministry of Education), Army Medical University (Third Military Medical University), Chongqing 400038, China.

作者： Ping,Deng ^[1] ; Jingdian,Li ^[1] ; Yonghui,Lu ^[1] ; Rongrong,Hao ^[1] ; Mindi,He ^[1] ; Min,Li ^[1] ; Miduo,Tan ^[2] ; Peng,Gao ^[1] ; Liting,Wang ^[3] ; Huihui,Hong ^[4] ; Jiawen,Tao ^[1] ; Muxue,Lu ^[5] ; Chunhai,Chen ^[1] ; Qinlong,Ma ^[1] ; Yang,Yue ^[1] ; Hui,Wang ^[1] ; Li,Tian ^[1] ; Jia,Xie ^[1] ; Mengyan,Chen ^[1] ; Yan,Luo ^[1] ; Zhengping,Yu ^[1] ; Zhou,Zhou ^[6] ; Huifeng,Pi ^[7]

作者单位： Department of Occupational Health (Key Laboratory of Electromagnetic Radiation Protection, Ministry of Education), Army Medical University (Third Military Medical University), Chongqing 400038, China. ^[1] Department of Breast Surgery, Central Hospital of Zhuzhou City, Central South University, Zhuzhou 412000, Hunan, China. ^[2] Biomedical Analysis Center, Army Medical University (Third Military Medical University), Chongqing 400038, China. ^[3] Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing 400030, China; Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China. ^[4] School of Medicine, Guangxi University, Nanning 530004, Guangxi, China. ^[5] Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing 400030, China. Electronic address: lunazhou00@cqu.edu.cn. ^[6] Department of Occupational Health (Key Laboratory of Electromagnetic Radiation Protection, Ministry of Education), Army Medical University (Third Military Medical University), Chongqing 400038, China; State key Laboratory Of Trauma and Chemical Poisoning, Army Medical University (Third Military Medical University), Chongqing 400038, China. Electronic address: pihuifeng@tmmu.edu.cn. ^[7]

关键词 Cadmium Ferroptosis Glutathione redox imbalance Kidney damage STEAP3