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Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression.

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第一作者： Nicola,Morrice

第一单位： Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.

作者： Nicola,Morrice ^[1] ; Susanne,Vainio ^[2] ; Kirsi,Mikkola ^[2] ; Lidy,van Aalten ^[1] ; Jennifer R,Gallagher ^[1] ; Michael L J,Ashford ^[1] ; Alison D,McNeilly ^[1] ; Rory J,McCrimmon ^[1] ; Alexandra,Grosfeld ^[3] ; Patricia,Serradas ^[4] ; Jukka,Koffert ^[5] ; Ewan R,Pearson ^[6] ; Pirjo,Nuutila ^[7] ; Calum,Sutherland ^[8]

作者单位： Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK. ^[1] Turku PET Centre, University of Turku, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland. ^[2] Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France. ^[3] Sorbonne Université, INSERM, Nutrition and Obesities: Systemic approaches, NutriOmics, Research group, F-75013, Paris, France. ^[4] Turku PET Centre, University of Turku, Turku, Finland; Department of Gastroenterology, Turku University Hospital, Turku, Finland. ^[5] Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK. ^[6] Turku PET Centre, University of Turku, Turku, Finland; Department of Endocrinology, Turku University Hospital, Turku, Finland. ^[7] Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK. Electronic address: c.d.sutherland@dundee.ac.uk. ^[8]

关键词 Diabetes Glucose-uptake Metformin Slc2a2 [(18)F]FDG-PET

DOI 10.1016/j.molmet.2023.101807

PMID 37717665

发布时间 2023-10-07

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Molecular metabolism

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Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression.

Molecular metabolism

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Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression.

Molecular metabolism

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Molecular metabolism

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