Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch.

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作者： Annie,Handler ^[1] ; Qiyu,Zhang ^[1] ; Song,Pang ^[2] ; Tri M,Nguyen ^[3] ; Michael,Iskols ^[1] ; Michael,Nolan-Tamariz ^[1] ; Stuart,Cattel ^[1] ; Rebecca,Plumb ^[1] ; Brianna,Sanchez ^[1] ; Karyl,Ashjian ^[1] ; Aria,Shotland ^[1] ; Bartianna,Brown ^[1] ; Madiha,Kabeer ^[1] ; Josef,Turecek ^[1] ; Michelle M,DeLisle ^[1] ; Genelle,Rankin ^[1] ; Wangchu,Xiang ^[1] ; Elisa C,Pavarino ^[1] ; Nusrat,Africawala ^[1] ; Celine,Santiago ^[1] ; Wei-Chung Allen,Lee ^[4] ; C Shan,Xu ^[2] ; David D,Ginty ^[5]

作者单位： Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. ^[1] Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. ^[2] Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. ^[3] Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA. ^[4] Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: david_ginty@hms.harvard.edu. ^[5]

关键词 Piezo2 focused ion beam scanning electron microscopy light touch mechanosensory neurons mechanotransduction touch end organs

主题词动物(Animals);默克尔细胞(Merkel Cells);动力传导, 细胞(Mechanotransduction, Cellular);成像, 三维(Imaging, Three-Dimensional);离子通道(Ion Channels);机械感受器(Mechanoreceptors);哺乳动物(Mammals)

DOI 10.1016/j.neuron.2023.08.023

PMID 37725982

发布时间 2024-10-19

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