首页> Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie> Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice.

Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice.

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第一作者： Serenella,Anzilotti

第一单位： Department of Science and Technology, University of Sannio, 82100 Benevento, Italy.

作者： Serenella,Anzilotti ^[1] ; Valeria,Valente ^[2] ; Paola,Brancaccio ^[3] ; Cristina,Franco ^[1] ; Antonella,Casamassa ^[4] ; Giovanna,Lombardi ^[1] ; Alessandra,Palazzi ^[2] ; Andrea,Conte ^[2] ; Simona,Paladino ^[2] ; Lorella Maria Teresa,Canzoniero ^[1] ; Lucio,Annunziato ^[4] ; Giovanna Maria,Pierantoni ^[5] ; Giuseppe,Pignataro ^[6]

作者单位： Department of Science and Technology, University of Sannio, 82100 Benevento, Italy. ^[1] Department of Molecular Medicine and Medical Biotechnology, School of Medicine, "Federico II" University of Naples, Italy. ^[2] Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences, School of Medicine, "Federico II" University of Naples, Italy. ^[3] IRCCS SYNLAB SDN S.p.A., 80143 Naples, Italy. ^[4] Department of Molecular Medicine and Medical Biotechnology, School of Medicine, "Federico II" University of Naples, Italy. Electronic address: gmpieran@unina.it. ^[5] Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences, School of Medicine, "Federico II" University of Naples, Italy. Electronic address: giuseppe.pignataro@unina.it. ^[6]

关键词 Amyotrophic Lateral Sclerosis Behavioral tests Cyanotoxin Mice Neurodegeneration l-BMAA

DOI 10.1016/j.biopha.2023.115503

PMID 37729728

发布时间 2023-10-17

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