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BRAF<sup>V600E</sup>-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism.

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第一作者： Paulina,Rzasa

第一单位： Leicester Cancer Research Centre, University of Leicester, Leicester, UK.

作者： Paulina,Rzasa ^[1] ; Sarah,Whelan ^[1] ; Pooyeh,Farahmand ^[1] ; Hong,Cai ^[1] ; Inna,Guterman ^[1] ; Raquel,Palacios-Gallego ^[1] ; Shanthi S,Undru ^[1] ; Lauren,Sandford ^[2] ; Caleb,Green ^[1] ; Catherine,Andreadi ^[1] ; Maria,Mintseva ^[3] ; Emma,Parrott ^[1] ; Hong,Jin ^[1] ; Fiona,Hey ^[1] ; Susan,Giblett ^[1] ; Nicolas B,Sylvius ^[4] ; Natalie S,Allcock ^[5] ; Anna,Straatman-Iwanowska ^[5] ; Roberto,Feuda ^[6] ; Cristina,Tufarelli ^[1] ; Karen,Brown ^[1] ; Catrin,Pritchard ^[1] ; Alessandro,Rufini ^[7]

作者单位： Leicester Cancer Research Centre, University of Leicester, Leicester, UK. ^[1] Leicester Cancer Research Centre, University of Leicester, Leicester, UK.;Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. ^[2] Leicester Cancer Research Centre, University of Leicester, Leicester, UK.;Area of Neuroscience, International School for Advanced Studies (SISSA), Trieste, Italy. ^[3] NUCLEUS Genomics, Core Biotechnology Services, University of Leicester, Leicester, UK. ^[4] University of Leicester Core Biotechnology Services Electron Microscopy Facility, Leicester, UK. ^[5] Department of Genetics and Genome Biology, University of Leicester, Leicester, UK. ^[6] Leicester Cancer Research Centre, University of Leicester, Leicester, UK. Alessandro.Rufini@unimi.it.;Dipartimento di Bioscienze, University of Milan, Milan, Italy. Alessandro.Rufini@unimi.it. ^[7]

医学主题词动物(Animals);人类(Humans);小鼠(Mice);胆固醇(Cholesterol);结直肠肿瘤(Colorectal Neoplasms);脂类代谢(Lipid Metabolism);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf);转录激活(Transcriptional Activation)

DOI 10.1038/s42003-023-05331-x

PMID 37735514

发布时间 2025-05-30

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Communications biology

2023年6卷1期

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Communications biology

2023年6卷1期

962页

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BRAF<sup>V600E</sup>-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism.

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BRAF<sup>V600E</sup>-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism.

Communications biology

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Communications biology

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