Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy.

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作者： Youngmi,Song ^[1] ; Hyekyung,Yang ^[1] ; Juhee,Kim ^[1] ; Yoonjin,Lee ^[1] ; Sung-Ho,Kim ^[2] ; In-Gu,Do ^[3] ; Cheol-Young,Park ^[4]

作者单位： Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. ^[1] LG Chem Life Sciences, Gangseo-gu, Seoul, South Korea. ^[2] Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. ^[3] Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: cydoctor@chol.com. ^[4]

关键词 Autophagy DPP-4 inhibitor Gemigliptin Inflammasome NASH ULK-1

主题词人类(Humans);小鼠(Mice);动物(Animals);二肽基肽酶Ⅳ抑制剂(Dipeptidyl-Peptidase IV Inhibitors);AMP活化蛋白激酶类(AMP-Activated Protein Kinases);炎性体(Inflammasomes);糖尿病, 2型(Diabetes Mellitus, Type 2);胆碱(Choline);疾病模型, 动物(Disease Models, Animal);甲硫氨酸(Methionine);自噬(Autophagy);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins)

DOI 10.1016/j.molmet.2023.101806

PMID 37739179

发布时间 2024-02-02

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Molecular metabolism

2023年78卷

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Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy.

Molecular metabolism

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Molecular metabolism

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Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy.

Molecular metabolism

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Molecular metabolism

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