Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model.

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第一作者： Inbal,Maniv

第一单位： Department of Biology, Technion Israel Institute of Technology, Haifa, 3200003, Israel.

作者： Inbal,Maniv ^[1] ; Mahasen,Sarji ^[1] ; Anwar,Bdarneh ^[1] ; Alona,Feldman ^[1] ; Roi,Ankawa ^[1] ; Elle,Koren ^[1] ; Inbar,Magid-Gold ^[1] ; Noa,Reis ^[1] ; Despina,Soteriou ^[1] ; Shiran,Salomon-Zimri ^[2] ; Tali,Lavy ^[1] ; Ellina,Kesselman ^[3] ; Naama,Koifman ^[3] ; Thimo,Kurz ^[4] ; Oded,Kleifeld ^[1] ; Daniel,Michaelson ^[2] ; Fred W,van Leeuwen ^[5] ; Bert M,Verheijen ^[6] ; Yaron,Fuchs ^[7] ; Michael H,Glickman ^[8]

作者单位： Department of Biology, Technion Israel Institute of Technology, Haifa, 3200003, Israel. ^[1] Department of Neurobiology, The George S. Wise Faculty of Life Sciences, The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978, Israel. ^[2] The Wolfson Department of Chemical Engineering, The Technion Center for Electron Microscopy of Soft Matter, Technion Israel Institute of Technology, Haifa, 3200003, Israel. ^[3] School of Molecular Biosciences, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK. ^[4] Department of Neuroscience, Maastricht University, 6229 ER, Maastricht, the Netherlands. ^[5] Department of Biology, Technion Israel Institute of Technology, Haifa, 3200003, Israel.;Department of Neuroscience, Maastricht University, 6229 ER, Maastricht, the Netherlands. ^[6] Department of Biology, Technion Israel Institute of Technology, Haifa, 3200003, Israel. yaronfox@gmail.com.;Augmanity, Rehovot, 7670308, Israel. yaronfox@gmail.com. ^[7] Department of Biology, Technion Israel Institute of Technology, Haifa, 3200003, Israel. glickman@technion.ac.il. ^[8]

主题词人类(Humans);阿尔茨海默病(Alzheimer Disease);信号传导(Signal Transduction);淀粉样β肽类(Amyloid beta-Peptides);淀粉样β蛋白前体(Amyloid beta-Protein Precursor)

DOI 10.1038/s41467-023-41545-7

PMID 37739965

发布时间 2023-11-19

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