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Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.

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第一作者： Xue,Wang

第一单位： Department of Urology, Ulm University Hospital, Helmholtzstr. 10, 89081, Ulm, Germany.;Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

作者： Xue,Wang ^[1] ; Junnan,Liu ^[2] ; Anca,Azoitei ^[3] ; Tim,Eiseler ^[4] ; Sabine,Meessen ^[5] ; Wencheng,Jiang ^[3] ; Xi,Zheng ^[6] ; Arika W,Makori ^[3] ; Markus,Eckstein ^[7] ; Arndt,Hartmann ^[7] ; Stephan,Stilgenbauer ^[8] ; Mohamed,Elati ^[9] ; Meike,Hohwieler ^[10] ; Alexander,Kleger ^[10] ; Axel,John ^[3] ; Friedemann,Zengerling ^[3] ; Felix,Wezel ^[3] ; Christian,Bolenz ^[3] ; Cagatay,Günes ^[11]

作者单位： Department of Urology, Ulm University Hospital, Helmholtzstr. 10, 89081, Ulm, Germany.;Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. ^[1] Department of Urology, Ulm University Hospital, Helmholtzstr. 10, 89081, Ulm, Germany.;Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. ^[2] Department of Urology, Ulm University Hospital, Helmholtzstr. 10, 89081, Ulm, Germany. ^[3] Department of Internal Medicine I, University Hospital, Ulm, Germany. ^[4] Department of Urology, Ulm University Hospital, Helmholtzstr. 10, 89081, Ulm, Germany.;Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. ^[5] Department of Urology, Ulm University Hospital, Helmholtzstr. 10, 89081, Ulm, Germany.;Department of Urology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.;Institute of Urology, Nanjing University, Nanjing, 210008, Jiangsu, China. ^[6] Institute of Pathology, Friedrich-Alexander University, Erlangen, Germany. ^[7] Department of Internal Medicine III, University Hospital, Ulm, Germany. ^[8] CANTHER, ONCOLille Institute, University of Lille, CNRS UMR 1277, Inserm U9020, 59045, Lille Cedex, France. ^[9] Institute of Mol. Oncology and Stem Cell Biology, University Hospital, Ulm, Germany. ^[10] Department of Urology, Ulm University Hospital, Helmholtzstr. 10, 89081, Ulm, Germany. Cagatay.guenes@uniklinik-ulm.de. ^[11]

关键词 Chromosomal imbalance Invadopodia Metastasis OSBPL3 Spindle orientation Urothelial carcinoma