Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity.

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作者： Anastasia O,Smirnova ^[1] ; Anna M,Miroshnichenkova ^[2] ; Laima D,Belyaeva ^[3] ; Ilya V,Kelmanson ^[2] ; Yuri B,Lebedev ^[4] ; Ilgar Z,Mamedov ^[2] ; Dmitriy M,Chudakov ^[5] ; Alexander Y,Komkov ^[2]

作者单位： Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, Russia. ^[1] Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. ^[2] Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates. ^[3] Department of Biomolecular Sciences and Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel. ^[4] Department of Molecular Technologies, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia. ^[5] Central European Institute of Technology, Masaryk University, Brno, Czechia. ^[6] Dmitry Rogachev National Medical and Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia. ^[7]

关键词 NGS - next generation sequencing T cell TRB repertoire Thymus VDJ recombination