Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system.

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作者： Francesco,Destro ^[1] ; John,Joseph ^[2] ; Prasanna,Srinivasan ^[2] ; Joshua M,Kanter ^[3] ; Caleb,Neufeld ^[2] ; Jacqueline M,Wolfrum ^[2] ; Paul W,Barone ^[2] ; Stacy L,Springs ^[2] ; Anthony J,Sinskey ^[2] ; Sylvain,Cecchini ^[4] ; Robert M,Kotin ^[3] ; Richard D,Braatz ^[3]

作者单位： Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[1] Center for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[2] Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA. ^[3] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[4] Carbon Biosciences, Waltham, MA 02451, USA. ^[5]

关键词 AAV-based gene therapy baculovirus expression vector system biomanufacturing gene therapy mechanistic modeling recombinant adeno-associated virus viral vector viral vector manufacturing

DOI 10.1016/j.omtm.2023.05.019

PMID 37746245

发布时间 2023-09-26

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Molecular therapy. Methods & clinical development

2023年30卷

122-146页

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Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

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Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

相关期刊

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