NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases.

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第一作者： Simone,Weber

第一单位： First Department of Medicine, University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

作者： Simone,Weber ^[1] ; Selina,Sitte ^[2] ; Anna-Lena,Voegele ^[1] ; Ludmilla,Sologub ^[2] ; Angelika,Wilfer ^[1] ; Timo,Rath ^[2] ; Andreas,Nägel ^[1] ; Sebastian,Zundler ^[2] ; Luigi,Franchi ^[1] ; Anthony W,Opipari ^[2] ; Sophia,Sonnewald ^[1] ; Stephen,Reid ^[2] ; Arndt,Hartmann ^[1] ; Philip,Eichhorn ^[2] ; Claudia,Handtrack ^[1] ; Klaus,Weber ^[2] ; Robert,Grützmann ^[3] ; Clemens,Neufert ^[3] ; Vera S,Schellerer ^[4] ; Elisabeth,Naschberger ^[4] ; Arif B,Ekici ^[5] ; Christian,Büttner ^[5] ; Markus F,Neurath ^[6] ; Raja,Atreya ^[6]

作者单位： First Department of Medicine, University Hospital Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[1] Deutsches Zentrum Immuntherapie [DZI], Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[2] SVP, Translational Medicine, Odyssey Therapeutics, Michigan, USA. ^[3] Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[4] Department of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[5] Department of Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[6] Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[7] Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[8]

关键词 IL-18 IL-1β Inflammatory bowel diseases NLRP3 inflammasome fibroblasts fibrosis mucosal immune system small molecule inhibitor