Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses.

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作者： Yutong,Wang ^[1] ; Li,Zhang ^[1] ; Wenqiang,Zhang ^[1] ; Mingshuang,Tang ^[1] ; Huijie,Cui ^[1] ; Xueyao,Wu ^[1] ; Xunying,Zhao ^[1] ; Lin,Chen ^[1] ; Peijing,Yan ^[1] ; Chao,Yang ^[1] ; Chenghan,Xiao ^[2] ; Yanqiu,Zou ^[1] ; Yunjie,Liu ^[1] ; Ling,Zhang ^[3] ; Chunxia,Yang ^[1] ; Yuqin,Yao ^[4] ; Jiayuan,Li ^[1] ; Zhenmi,Liu ^[2] ; Xia,Jiang ^[5] ; Ben,Zhang ^[6]

作者单位： Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, Section 3, South Renmin Road, Wuhou District, Chengdu, 610041, Sichuan, China. ^[1] Department of Maternal, Child and Adolescent Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. ^[2] Department of Iatrical Polymer Material and Artificial Apparatus, School of Polymer Science and Engineering, Sichuan University, Chengdu, China. ^[3] Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. ^[4] Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, Section 3, South Renmin Road, Wuhou District, Chengdu, 610041, Sichuan, China. xiajiang@scu.edu.cn. ^[5] Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. xiajiang@scu.edu.cn. ^[6] Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. xiajiang@scu.edu.cn. ^[7] Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, Section 3, South Renmin Road, Wuhou District, Chengdu, 610041, Sichuan, China. wcsphwcfh@vip.163.com. ^[8]

关键词 Chronic kidney disease Genetic correlation Genome-wide cross-trait analysis Kidney function Lipids Mendelian randomization

主题词人类(Humans);全基因组关联研究(Genome-Wide Association Study);前瞻性研究(Prospective Studies);胆固醇, HDL(Cholesterol, HDL);胆固醇, LDL(Cholesterol, LDL);肾功能不全, 慢性(Renal Insufficiency, Chronic)

DOI 10.1186/s12967-023-04509-5

PMID 37759214

发布时间 2023-11-21

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