首页> Molecular therapy : the journal of the American Society of Gene Therapy> Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy.

Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy.

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第一作者： Boaz,Wong

第一单位： Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

作者： Boaz,Wong ^[1] ; Anabel,Bergeron ^[1] ; Glib,Maznyi ^[2] ; Kristy,Ng ^[2] ; Anna,Jirovec ^[1] ; Harsimrat K,Birdi ^[1] ; Daniel,Serrano ^[2] ; Marcus,Spinelli ^[2] ; Max,Thomson ^[2] ; Zaid,Taha ^[1] ; Akram,Alwithenani ^[1] ; Andrew,Chen ^[2] ; Ian,Lorimer ^[2] ; Barbara,Vanderhyden ^[2] ; Rozanne,Arulanandam ^[3] ; Jean-Simon,Diallo ^[4]

作者单位： Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[1] Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. ^[2] Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. Electronic address: rarulanandam@ohri.ca. ^[3] Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: jsdiallo@ohri.ca. ^[4]

关键词 cancer innate immunity interferon neddylation oncolytic virotherapy pevonedistat viral enhancement